Azelaic Acid vs. Niacinamide for Rosacea

Both reduce redness, but they work differently. Here’s a quick way to choose, and how to layer them if you want the best of both.

Quick Take

• Choose Azelaic if you have persistent redness, texture/bumps, or post-inflammatory marks.
• Choose Niacinamide if you’re very sensitive and want barrier support with minimal sting.
• Use Both by alternating days or layering (niacinamide → azelaic) if skin tolerates.

Benefits & Mechanisms

Azelaic Acid

• Helps visible redness and papules.
• Refines look of texture and tone irregularities.
• May tingle initially; start slowly.

Niacinamide

• Supports barrier function; reduces water loss.
• Calms look of redness and blotchiness.
• Usually very well tolerated; pairs with most actives.

Tolerability & Side Effects

Azelaic can tingle or sting at first—patch test and ramp up. Niacinamide is typically gentle; rare flushing can occur at very high percentages.

Can You Use Them Together?

Yes. For most, apply niacinamide first (watery serum), let it settle, then apply azelaic (gel/cream). If irritation appears, alternate days.

Sample Routines

Round out your routine with a barrier cream and a mineral sunscreen. See: Best Moisturizers for Rosacea and Best Mineral Sunscreens for Rosacea.

Unsure about a product’s ingredients? Paste the INCI into the Ingredient Checker Tool to flag potential triggers.

Want a tailored plan? Chat with SkinGPT Advisor for step-by-step AM/PM guidance.